|
|
testosterone + NAD+ <=> 4-androstene-3,17-dione + NADH + H+
|
1.1.1.112
indanol dehydrogenase
1.1.1.210
3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
1.1.1.64
testosterone 17beta-dehydrogenase (NADP+)
|
–
–
–
–
–
–
–
|
BK
|
| |
BRENDA:
BR29275
KEGG:
R01836
MetaCyc:
1.1.1.51-RXN_WOP;
TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN
SABIO-RK:
1915
|
|
|
|
testosterone + NADP+ <=> 4-androstene-3,17-dione + NADPH + H+
|
1.1.1.146
11beta-hydroxysteroid dehydrogenase
1.1.1.148
estradiol 17alpha-dehydrogenase
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
1.1.1.64
testosterone 17beta-dehydrogenase (NADP+)
|
–
–
–
–
–
–
–
–
–
–
–
|
BMK
|
| |
BRENDA:
BR29315;
BS438469
KEGG:
R01838
MetaCyc:
1.1.1.51-RXN;
1.1.1.64-RXN
SABIO-RK:
1917
|
|
|
|
testosterone + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> 1alpha-hydroxytestosterone + oxidized_ferredoxin + H2O
|
1.14.15.19
C-19 steroid 1alpha-hydroxylase
|
–
|
|
| |
BRENDA:
BR51702
KEGG:
R11349
MetaCyc:
RXN-17520
|
|
|
|
5alpha-dihydrotestosterone + NADP+ <=> testosterone + H+ + NADPH
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
1.3.99.5
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
|
–
–
|
MK
|
| |
BRENDA:
BS258429
KEGG:
R02497
MetaCyc:
RXN66-343
SABIO-RK:
11551
|
|
|
|
testosterone + acceptor <=> 1,4-androstadien-17beta-ol-3-one + reduced_acceptor
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
M
|
| |
BRENDA:
BS258846
MetaCyc:
RXN-21484
|
|
|
|
3''-phosphoadenylyl-sulfate + testosterone <=> adenosine_3,5''-bisphosphate + testosterone_sulfate + H+
|
2.8.2.15
steroid sulfotransferase
2.8.2.2
alcohol sulfotransferase
2.8.2.32
scymnol sulfotransferase
|
–
–
–
|
|
| |
BRENDA:
BS360204;
BS360259
MetaCyc:
RXN-20217
|
|
|
|
testosterone + 3 O2 + 3 reduced_flavodoxin <=> 17beta-estradiol + formate + 4 H2O + 3 flavin
|
1.14.14.14
aromatase
|
–
|
|
| |
BRENDA:
BR50742
KEGG:
R10511
|
|
|
|
testosterone + O2 + reduced_flavodoxin <=> 19-hydroxytestosterone + H2O + flavin
|
1.14.14.14
aromatase
|
–
|
K
|
| |
BRENDA:
BR50743
KEGG:
R02501
|
|
|
|
testosterone + NADPH + H+ <=> 5beta-dihydrotestosterone + NADP+
|
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
|
–
|
K
|
| |
BRENDA:
BS258366
KEGG:
R02498
SABIO-RK:
10859
|
|
|
|
UDP-glucuronate + testosterone <=> UDP + epitestosterone_O-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
K
|
| |
BRENDA:
BS402159
KEGG:
R02502
SABIO-RK:
2430
|
|
|
|
androstenediol + NAD+ <=> testosterone + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
|
K
|
| |
BRENDA:
BS404313
KEGG:
R02499
|
|
|
|
testosterone + NADPH + H+ <=> 4-androsten-3alpha,17beta-diol + NADP+
|
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.3.1.20
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
|
–
–
–
–
|
|
| |
BRENDA:
BS231985
SABIO-RK:
13073
|
|
|
|
testosterone + NADPH + H+ <=> 4-Androsten-3beta,17beta-diol + NADP+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.184
carbonyl reductase (NADPH)
|
–
–
|
|
| |
BRENDA:
BS257048
SABIO-RK:
2428
|
|
|
|
testosterone + NADPH + O2 <=> 6beta-hydroxytestosterone + NADP+ + H2O
|
1.14.14.1
unspecific monooxygenase
1.14.14.25
cholesterol 24-hydroxylase
1.14.14.55
quinine 3-monooxygenase
1.14.14.57
taurochenodeoxycholate 6alpha-hydroxylase
1.14.99.4
progesterone monooxygenase
|
–
–
–
–
–
|
|
| |
BRENDA:
BS287906
SABIO-RK:
7146
|
|
|
|
testosterone + reduced_flavodoxin + O2 <=> 7alpha,17beta-dihydroxyandrost-4-en-3-one + flavin + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
K
|
| |
KEGG:
R02503
|
|
|
|
testosterone + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 17beta-estradiol + oxidized_[NADPH-hemoprotein_reductase] + H2O + formate + H+
|
1.14.14.14
aromatase
|
–
|
|
| |
MetaCyc:
RXN-14744
|
|
|
|
testosterone + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 19-hydroxytestosterone + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
not assigned
|
–
|
M
|
| |
MetaCyc:
RXN66-347
|
|
|
|
testosterone + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 6beta-hydroxytestosterone + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
|
| |
MetaCyc:
RXN66-591
|
|
|
|
testosterone + 3 O2 + 3 reduced_flavoproteins <=> 17beta-estradiol + formate + 4 H2O + 3 oxidized_flavoproteins
|
1.14.14.14
aromatase
|
–
|
|
| |
BRENDA:
BS425049
|
|
|
|
testosterone + reduced_adrenodoxin + O2 <=> 11-hydroxytestosterone + oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
| |
BRENDA:
BS427105
|
|
|
|
testosterone + 2 reduced_ferredoxin_[iron-sulfur]_cluster + 2 H+ + O2 <=> 9alpha,17beta-dihydroxy-4-androstene-3-one + 2 oxidized_ferredoxin + H2O
|
1.14.15.30
3-ketosteroid 9alpha-monooxygenase
|
–
|
|
| |
BRENDA:
BS418287
|
|
|
|
testosterone + reduced_flavodoxin + O2 <=> 6beta-hydroxytestosterone + flavin + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
|
| |
BRENDA:
BS410361
|
|
|
|
testosterone + H2O2 <=> 17beta-hydroxy-4,5-epoxy-5beta-androstan-3-one + 16alpha,17beta-Dihydroxyandrost-4-en-3-one + H2O
|
1.11.2.1
unspecific peroxygenase
|
–
|
|
| |
BRENDA:
BS442019
|
|
|
|
testosterone + 2,6-dichlorophenolindophenol <=> 1,4-androstadien-17beta-ol-3-one + reduced_2,6-dichlorophenolindophenol
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
| |
BRENDA:
BS442017
|
|
|
|
testosterone + 2,6-dichlorophenolindophenol <=> 1,4-androstadiene-17beta-ol-3-one + reduced_2,6-dichlorophenolindophenol
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
| |
BRENDA:
BS440841
|
|
|
|
testosterone + UDP-glucuronate <=> UDP + testosterone_O-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
| |
BRENDA:
BS322176
|
|
|
|
testosterone + UDP-glucuronate <=> UDP + testosterone-17-O-alpha-D-glucuronate
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
| |
BRENDA:
BS389863
|
|
|
|
4-androstene-3,17-dione + reduced_acceptor + O2 <=> testosterone + 14alpha-hydroxyandrost-4-ene-3,17-dione + 11alpha-hydroxyandrost-4-ene-3,17-dione + 15beta-hydroxytestosterone + 11alpha-hydroxytestosterone + 15alpha-hydroxytestosterone + A + H2O
|
1.14.99.12
androst-4-ene-3,17-dione monooxygenase
|
–
|
|
| |
BRENDA:
BS443053
|
|
|
|
4-androstene-3,17-dione + reduced_acceptor + O2 <=> testosterone + 11beta-hydroxyandrost-4-ene-3,17-dione + testololactone + A + H2O
|
1.14.99.12
androst-4-ene-3,17-dione monooxygenase
|
–
|
|
| |
BRENDA:
BS443052
|
|
|
|
testosterone + reduced_ferredoxin + O2 <=> 11beta-hydroxytestosterone + oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
| |
BRENDA:
BS377855
|
|
|
|
testosterone + reduced_acceptor + O2 <=> 15beta-hydroxytestosterone + oxidized_acceptor + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
| |
BRENDA:
BS406747
|
|
|
|
testosterone + reduced_adrenodoxin + O2 <=> 15beta-hydroxytestosterone + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
| |
BRENDA:
BS406748
|
|
|
|
testosterone + reduced_megaredoxin + O2 <=> 15beta-hydroxytestosterone + oxidized_megaredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
| |
BRENDA:
BS406749
|
|
|
|
5alpha-dihydrotestosterone + NADH + H+ <=> testosterone + NADH + H+
|
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
|
–
|
|
| |
BRENDA:
BS438918
|
|
|
|
testosterone_3-sulfate + H2O <=> testosterone + sulfate
|
3.1.6.1
arylsulfatase
3.1.6.2
steryl-sulfatase
|
–
–
|
|
| |
BRENDA:
BS448161
|
|
|
|
testosterone + reduced_acceptor + O2 <=> 11alpha-hydroxytestosterone + A + H2O
|
1.14.99.14
progesterone 11alpha-monooxygenase
|
–
|
|
| |
BRENDA:
BS415776
|
|
|
|
testosterone + NADH <=> 5beta-dihydrotestosterone + NAD+
|
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.3.99.6
3-oxo-5beta-steroid 4-dehydrogenase
|
–
–
|
|
| |
BRENDA:
BS258874
|
|
|
|
testosterone + NADH + H+ <=> 4-androsten-3alpha,17beta-diol + NAD+
|
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
|
–
|
|
| |
BRENDA:
BS374702-a
|
|
|
|
5beta-dihydrotestosterone + NADH + H+ <=> testosterone + NAD+
|
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS403316-a
|
|
|
|
androstenediol + NADH + H+ <=> testosterone + NAD+
|
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS404314-a
|
|
|
|
4-Androsten-3beta,17beta-diol + NAD+ <=> testosterone + NADH
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS257034
|
|
|
|
DELTA5-androstenediol + NAD+ <=> testosterone + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS438313
|
|
|
|
testosterone + NADH + H+ <=> 4-androstene-3,17-dione + NAD+
|
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
|
–
|
|
| |
BRENDA:
BS425050-a
|
|
|
|
testosterone + NADPH <=> 5alpha-androstane-3alpha,17beta-diol + androstane-3beta,17beta-diol + 5alpha-dihydrotestosterone
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
|
–
|
|
| |
BRENDA:
BS258534
|
|
|
|
Epitestosterone + NADP+ <=> testosterone + NADPH + H+
|
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS187709
|
|
|
|
testosterone + NADP+ <=> 4-androstene-3,17-dione + NADH + H+
|
1.1.1.112
indanol dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
|
|
| |
BRENDA:
BS187030
|
|
|
|
5beta-dihydrotestosterone + NADPH + H+ <=> testosterone + NADP+
|
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS403316
|
|
|
|
androstenediol + NADPH + H+ <=> testosterone + NADP+
|
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS404314
|
|
|
|
testosterone + NADPH + H+ <=> 4-androstene-3,17-dione + NADP+
|
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
|
–
|
|
| |
BRENDA:
BS425050
|
|
|
|
UDP-glucose + testosterone <=> UDP + testosterone-17-yl_beta-D-glucopyranoside
|
2.4.1.173
sterol 3beta-glucosyltransferase
2.4.1.B4
|
–
–
|
|
| |
BRENDA:
BS402187
|
|
|
|
testosterone + reduced_acceptor + O2 <=> 15alpha-hydroxytestosterone + 15beta-hydroxytestosterone + 2beta-hydroxytestosterone + acceptor + H2O
|
1.14.99.4
progesterone monooxygenase
|
–
|
|
| |
BRENDA:
BS451390
|
|
|
|
5beta-dihydrotestosterone + menadione <=> testosterone + reduced_acceptor
|
1.3.99.6
3-oxo-5beta-steroid 4-dehydrogenase
|
–
|
|
| |
BRENDA:
BS258882
|
|
|
|
testosterone + reduced_acceptor <=> 5alpha-dihydrotestosterone + acceptor
|
1.3.99.5
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
|
–
|
|
| |
BRENDA:
BS258869
|
|
|
|
testosterone_oleate + H2O <=> testosterone + oleic_acid
|
3.1.1.79
hormone-sensitive lipase
|
–
|
|
| |
BRENDA:
BS374705
|
|
|
|
testosterone + O2 + H+ + NADPH <=> NADP+ + H2O + 15beta-hydroxytestosterone
|
1.14.14.55
quinine 3-monooxygenase
|
–
|
|
| |
SABIO-RK:
7143
|
|
|
|
NADPH + testosterone + O2 + H+ <=> NADP+ + H2O + 2beta-hydroxytestosterone
|
1.14.14.55
quinine 3-monooxygenase
|
–
|
|
| |
SABIO-RK:
7145
|
|
|
|
testosterone + O2 + H+ + NADPH <=> H2O + 1beta-Hydroxytestosterone + NADP+
|
1.14.14.55
quinine 3-monooxygenase
|
–
|
|
| |
SABIO-RK:
7144
|
|
|
|
H+ + O2 + NADPH + testosterone <=> H2O + NADP+ + formate + 17beta-estradiol
|
1.14.14.1
unspecific monooxygenase
|
–
|
|
| |
SABIO-RK:
9545
|
|
|
|
testosterone + NADPH + H+ + O2 <=> H2O + 16beta-Hydroxytestosterone + NADP+
|
1.14.14.25
cholesterol 24-hydroxylase
|
–
|
|
| |
SABIO-RK:
13213
|
|
|
|
NADPH + H+ + O2 + testosterone <=> NADP+ + 2-Hydroxytestosterone + H2O
|
1.14.14.25
cholesterol 24-hydroxylase
|
–
|
|
| |
SABIO-RK:
13212
|
|
